- Active Substance: Retatrutide
- Concentration: 20 mg per vial
- Pack Size: 1 vial
- Manufacturer: Generic Peptides
- Brand Name: Retatrutide
- Synonyms: LY3437943
- Molecular Formula: C187H291N51O58
- Molecular Weight: ~4200 g/mol
- Sequence: Proprietary Analog of GLP-1/GIP/Glucagon Tri-agonist
SKU: P4373
Retatrutide 20 mg – High-Dose Tri-Agonist Peptide for Human Metabolic Health and Longevity Research
Product Information
Retatrutide 20 mg is a high-strength peptide designed to mimic and enhance the body's natural hormonal pathways involved in appetite control, energy metabolism, and insulin regulation. In a clinical context, this formulation would provide long-lasting activation of three important receptors: GLP-1, GIP, and glucagon. These pathways work synergistically to reduce body fat, improve glucose control, and support cardiovascular and metabolic health. Retatrutide is structurally optimized for prolonged activity and reduced degradation, potentially allowing for once-weekly administration. Its 20 mg dosage format is ideal for cases requiring stronger or more sustained metabolic modulation.
Product Description
As a tri-agonist peptide, Retatrutide is a next-generation compound that targets multiple incretin and glucagon pathways in a single molecule. In hypothetical therapeutic scenarios, it could help individuals manage body weight, enhance insulin sensitivity, and reduce visceral fat. The 20 mg dose offers a convenient, higher-strength option that may be suitable for those requiring robust metabolic intervention. Unlike single-pathway peptides, Retatrutide's multi-receptor engagement could produce broader and more sustained effects on weight loss and glycemic control. It is currently under advanced clinical investigation and represents a promising tool in the future of endocrine and metabolic care.
Mechanism of Action
Retatrutide activates three critical receptors: GLP-1R (glucagon-like peptide-1 receptor), GIPR (gastric inhibitory polypeptide receptor), and GCGR (glucagon receptor). GLP-1R activation suppresses appetite and delays gastric emptying, while enhancing glucose-dependent insulin secretion. GIPR stimulation further boosts insulin output and may improve lipid metabolism. GCGR activation increases energy expenditure and promotes fat breakdown (lipolysis), potentially aiding body recomposition. Together, these pathways work to optimize blood sugar regulation, reduce food intake, and promote fat burning—key factors in managing metabolic syndrome and age-related health decline.
Use Case
In the context of clinical anti-aging and metabolic optimization, Retatrutide 20 mg may be hypothetically used to improve insulin resistance, reduce central adiposity, and enhance energy regulation. For aging individuals facing weight gain, glucose intolerance, or reduced metabolic flexibility, this tri-agonist formulation could theoretically offer comprehensive support. Its combined action might promote lean mass preservation while targeting visceral fat stores, offering significant quality-of-life improvements. Though still under clinical review, Retatrutide could eventually represent a safe, long-acting solution for sustained metabolic health and weight control. It is especially promising for individuals who have not responded well to mono-agonist therapies.
FAQ
What are the potential benefits of Retatrutide?
Retatrutide may promote fat loss, improve insulin sensitivity, suppress appetite, and enhance metabolic efficiency. Its triple-receptor activity offers broad therapeutic potential across obesity, diabetes, and longevity medicine.
How does Retatrutide compare to GLP-1 agonists like Semaglutide?
Unlike single-agonist therapies like Semaglutide, Retatrutide activates GLP-1, GIP, and glucagon receptors simultaneously. This could translate to stronger and more durable effects on fat loss, glucose control, and energy balance.
Is Retatrutide available for therapeutic use?
No, Retatrutide is not approved for medical use and is currently in clinical trial phases. It is not legally available for prescription or personal use outside approved research settings.
Legal & Compliance
This product is intended strictly for laboratory and research use only. It is not approved for human consumption, therapeutic application, or diagnostic use. Purchase is restricted to qualified professionals and research institutions. All buyers must comply with applicable federal, state, and local regulations. Use outside of controlled research settings is strictly prohibited and may result in regulatory or legal action.